CBD Oil Benefits
CBD Oil contains cannabidiol and often other cannabinoid compounds in an oil suspension called a carrier oil. CBD Oil is available in various forms such as tinctures, softgel capsules and sprays and is typically ingested orally. Topical CBD such as balms and creams can be applied to the skin. The concentration of CBD varies from product to product.
The Health Benefits of CBD Oil
CBD Oil benefits for the human and mammalian body are indeed numerous. It exhibits potent antioxidant, analgesic, anti-cancer, anti-inflammatory and antipsychotic effects. It alleviates the cognitive decline associated with ageing, and it also reduces the risk of diabetes.
The Health Effects of Cannabis and Cannabinoids: View Research Paper
- In adults with chemotherapy-induced nausea and vomiting, oral cannabinoids are effective antiemetics.
- In adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms.
- In adults with multiple sclerosis (MS)-related spasticity, short-term use of oral cannabinoids improves patient-reported spasticity symptoms.
Cannabidiol and the Immune System
The immune system is comprised of structures and processes within the body that protect against diseases and destroy foreign and infectious microbes. In some instances, the immune system mistakenly attacks healthy tissue, resulting in a condition known as autoimmunity. Cannabidiol (CBD) has been shown by researchers to be an immune system suppressor: one of the reasons why it’s useful in the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and Crohn’s disease, and why it has improved the quality of life of those suffering from such diseases. The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT) View Research Paper
Taken together, these data suggest that CBD suppresses T cell function and that CB1 and/or CB2 play a critical role in the magnitude of the in vitro anti-sRBC IgM AFC response. CBD possesses a low affinity for both CB1 and CB2 cannabinoid receptors and therefore, does not produce the “high” associated with marijuana use. Despite this, CBD does exhibit immunosuppressive properties.
Cannabidiol and the Sleep Cycle
According to research, Cannabidiol improves insomnia and increases the amount of sleep because it reduces anxiety and chronic pain, as opposed to making one sleepy. Interestingly, Cannabidiol has also been shown to induce alertness when awake, and it has also been shown to improve REM Sleep Disorder.
Chart of the Medicinal Benefits of Cannabinoids
CBD Oil Benefits For Psychological Conditions
A great deal of research has found that CBD Oil benefits various psychological conditions such as:
- Attention Deficit Hyperactivity Disorder (ADHD)
- Attention-Deficit Disorder (ADD)
- Obsessive-Compulsive Disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Phantom Limb
CBD Oil Benefits For Physiological Conditions
CBD Oil benefits various physiological conditions, as verified by research, such as:
- Amyotrophic Lateral Sclerosis (ALS)
- Gastrointestinal Disorders
- Multiple Sclerosis (MS)
- Muscular Dystrophy
- Spinal injury
CBD for Acne
Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
CBD for Arthritis
The data presented here indicate that local administration of CBD blocked OA pain. Prophylactic CBD treatment prevented the later development of pain and nerve damage in these OA joints. These findings suggest that CBD may be a safe, useful therapeutic for treating OA joint neuropathic pain.
Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.
CBD as an Anti-Inflammatory
Cannabinoids as a novel anti-inflammatory: View Research Paper
Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2). The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
CBD for Anxiety
Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations. Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects.
CBD for Alzheimer’s
CBD for ADD/ADHD
ADD/ADHD symptoms are typified by low dopamine and high cortisol levels and can be reduced by CBD , which increases dopamine and lowers cortisol levels in the body. While some studies have investigated cannabis as a treatment for symptoms of ADD/ADHD, few have considered the efficacy of CBD in particular. However, there is a great deal of anecdotal evidence supporting the effectiveness of CBD as a treatment for symptoms of ADD/ADHD.
Cannabinoids in attention-deficit/hyperactivity disorder: View Research Paper
Adults with ADHD may represent a subgroup of individuals who experience a reduction of symptoms and no cognitive impairments following cannabinoid use. While not definitive, this study provides preliminary evidence supporting the self-medication theory of cannabis use in ADHD and the need for further studies of the endocannabinoid system in ADHD.
CBD for Autism
In this review we summarize the available pre-clinical and clinical data regarding the safety and effectiveness of medical cannabis, including CBD, in young ASD patients. Cannabidiol seems to be a candidate for the treatment of ASD.
Results: Following the cannabis treatment, behavioral outbreaks were much improved or very much improved (on the CGIC scale) in 61% of patients. The anxiety and communication problems were much or very much improved in 39% and 47% respectively. Disruptive behaviors, were improved by 29% from 4.74±1.82 as recorded at baseline on the HSQ-ASD to 3.36±1.56 following the treatment. Parents reported less stress as reflected in the APSI scores, changing by 33% from 2.04±0.77 to 1.37±0.59. The effect on all outcome measures was more apparent in boys with non-syndromic ASD. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%).
Conclusions: This preliminary study support the feasibility of CBD based medical cannabis as a promising treatment option for refractory behavioral problems in children with ASD. Based on these promising results, we have launched a large, double blind, placebo controlled cross-over trial with 120 participants.
Results: 53 children at a median age of 11 (4-22) year received Cannabidiol for a median duration of 66 days (30-588). Self-injury and rage attacks (n = 34) improved in 67.6% and worsened in 8.8%. Hyperactivity symptoms (n = 38) improved in 68.4%, did not change in 28.9% and worsened in 2.6%. Sleep problems (n = 21) improved in 71.4% and worsened in 4.7%. Anxiety (n = 17) improved in 47.1% and worsened in 23.5%. Adverse effects, mostly somnolence and change in appetite were mild. Conclusion: Parents’ reports suggest that Cannabidiol may improve ASD comorbidity symptoms; however, the long-term effects should be evaluated in large scale studies.
This retrospective study assessed tolerability and efficacy of Cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients.
CBD for Cancer
Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
This study reveals that CBD inhibits angiogenesis by multiple mechanisms. Its dual effect on both tumour and endothelial cells supports the hypothesis that CBD has potential as an effective agent in cancer therapy.
Altogether, these findings provide a novel mechanism underlying the anti-invasive action of Cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers.
CBD for Epilepsy
CBD treatment yielded a significant positive effect on seizure load. Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported <25% reduction. Five (7%) patients reported aggravation of seizures which led to CBD withdrawal. In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep.
Seven out of the eight epileptics receiving Cannabidiol had improvement of their disease state, whereas only one placebo patient improved.
CBD for Multiple Sclerosis (MS)
There is evidence that CBD has a number of beneficial pharmacological effects (4, 5). It is anti-inflammatory, antioxidative, antiemetic, antipsychotic, and neuroprotective. The review of 132 original studies by Bergamaschi et al. (6) describes the safety profile of CBD by highlighting that catalepsy is not induced and physiological parameters (heart rate, blood pressure, and body temperature) are not altered. Moreover, psychomotor and psychological functions are not negatively affected. Currently, many PwMS utilize cannabis to manage a variety of symptoms. Kindred et al.) showed in a web-based survey, which was hosted by the National Multiple Sclerosis Society that 66% of PwMS currently use cannabis for symptom treatment. Cannabidiol Reduces Spasticity, Pain, Inflammation, Fatigue, and Depression in PwMS.
CBD for Pain Management
Cannabinoids in the management of difficult to treat pain: View Research Paper
Cannabidiol, a non-euphoriant phytocannabinoid common in certain strains, shares neuroprotective effects with THC, inhibits glutamate neurotoxicity, and displays antioxidant activity greater than ascorbic acid (vitamin C) or tocopherol (vitamin E). CBD additionally affects THC function by inhibiting first-pass hepatic metabolism to the possibly more psychoactive 11-hydroxy-THC, prolonging its half-life, and reducing associated intoxication, panic, anxiety and tachycardia. Additionally, CBD is able to inhibit tumor necrosis factor-alpha (TNF-α) in its own right in a rodent model of rheumatoid arthritis.
CBD for Post Traumatic Stress Disorder (PTSD)
How Should I Take CBD Oil?
CBD-based supplements are most commonly taken orally as drops. Take your drops sublingually, or under your tongue and hold there for around a minute before swallowing. This action allows the drops to be diffused through the mucous membranes beneath your tongue. Because there are a great many capillaries under the tongue, it has a direct route into your bloodstream, allowing it to work faster and more efficiently. Taking your drops sublingually is preferable to swallowing immediately. The reason is that it must first pass through your gastrointestinal tract, the stomach and the intestines where most absorption takes place, but also where some of the CBD may be destroyed stomach acids. Then it is filtered by the liver before entering the bloodstream. CBD capsules can be swallowed immediately and are preferred by those that can’t handle the taste of CBD. It should be noted that however, that higher dosages may be required as less of the CBD may enter the bloodstream as a result of the destructive effects of the digestive system.
How Much CBD Oil Should I Take?
Ideally, your dosage should be prescribed by a qualified and experienced healthcare professional. Various brands have products offering different strengths. Also, different conditions require different dosages to be effective, and some people may need more than others to have the desired effect. Typically, one should start with the recommended dose for a week and build up weekly in small increments until no further benefit is felt. Then, gradually reduce the dosage incrementally until you find an ideal dosage for the desired effect.
How Long Does it Take to Feel the Effect?
The time it takes for the effects of CBD to manifest when taken orally depends a great deal on how long ago your last meal was, and how much you ate. Typically, it’s best to take CBD on an empty stomach for the effects to be felt more immediately, as the more substantial and more recently, a meal was eaten, the more delayed the effects.
What are the Side Effects of CBD?
Most importantly, CBD will not cause you to get “high” or experience a sensation of intoxication as it contains virtually no THC, making it non-psychoactive. It will not adversely affect your sensory perception, reflexes, reaction time or your behaviour in general.
Is it Safe to Take?
CBD is safe and non-toxic even at high dosages. According to CannLabs, a testing lab for cannabis products, there is no established lethal dosage of CBD, and interestingly, there have been no reported cases of CBD overdosage.
Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters.
In general, the often described favorable safety profile of CBD in humans was confirmed and extended by the reviewed research. The majority of studies were performed for treatment of epilepsy and psychotic disorders. Here, the most commonly reported side effects were tiredness, diarrhea, and changes of appetite/weight. In comparison with other drugs, used for the treatment of these medical conditions, CBD has a better side effect profile.
What is the Recommended Dose?
While there is no RDA or officially recommended dose for CBD, there are various clinical studies, research papers and resources from which such information can be drawn:
- Preventative: Up to 10mg/day
- Anxiety: 15 – 25mg/day (Source: Reddit Dosage question about help with anxiety)
- Cancer: 500 – 1000+mg/day or 10mg/kg/day (Source: Cannabidiol as potential anticancer drug)
- Chronic Pain: 2.5 – 20mg/day (Source: Cannabinoids as novel anti-inflammatory drugs)
- Epilepsy: 200 – 300mg/day or 20mg/kg (Source: Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome)
- Glaucoma: 15 – 40mg/day (Source: Neuroprotective Effect of(-)?9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity)
- Sleep Disorders: 50 – 150mg/day (Source: Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report)
- Schizophrenia: 400 – 1250mg/day (Source: A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol as a Treatment for Acutely Ill Schizophrenic Patients)
Scientific studies are now bolstering what was once just anecdotal evidence for the effectiveness of CBD Oil in the treatment of many ailments and maladies. As always, seek medical advice before trying any new course of treatment.
For more information, view our informative article CBD Oil | South Africa | Facts and Information.
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